Services & Facilities

IGSB features state-of-the-art core technologies at the University of Chicago and Argonne National Laboratory. These facilities support efforts to define the complex genetics underlying disease and the development of potential therapeutics to target disease pathways.

Current IGSB Core Facilities include:

Advance Imaging Core (AIC)

• Two Digital Scanned Laser Light Sheet Fluorescence Microscopes (DSML)
• Advanced image analysis expertise
• Specialize in large-scale custom imaging projects

BAC-Recombineering Core (BRC)

• Protein tags (GFP, etc) for imaging, ChIP-Chip, ChIP-seq, or in situ hybridization experiments
• Custom modifications of BACs including deletions, insertions, substitutions, fusions
• In vitro DNA synthesis for custom projects (mutagenesis, codon optimization, etc.)

Celluar Screening Center (CSC)

• High-throughput screening of small molecule and whole genome siRNA libraries
• Assay development and optimization into 96, 384, or 1536 well micro titer plates including high content screening

High-throughput Genome Analysis Core (HGAC)

• Next generation sequencing portfolio comprising 3 Illumina HiSeq2000s and 1 Illumina MiSeq
• Support a complete range of applications such as RNASeq, ChIP-Seq, exome and whole genome sequencing
• Data delivered through Bionimbus, an open sourced and secure cloud system for anytime-anywhere data analysis and interpretation

Micro-Western Array Core (MWAC)

• High-throughput quantification of abundance and modification of pre-selected protein targets

Any questions regarding the Institute’s facilities should be addressed to Liza Herendeen, IGSB Business Administrator email: .(JavaScript must be enabled to view this email address) (773) 834-3913