Research Papers
- Light-Driven Changes in Energy Metabolism Directly Entrain the Cyanobacterial Circadian Oscillator
- A Vision for a Biomedical Cloud (J Intern Med. 2011 Dec 5. doi: 10.1111/j.1365-2796.2011.02491)
- Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness (Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America)
- Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.
- Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data (Proc Natl Acad Sci U S A. 2011 Jul 5.)
- A user's guide to the encyclopedia of DNA elements (ENCODE). (PLoS Biol. 2011 Apr;9(4):e1001046. Epub 2011 Apr 19)
Metabolic Diseases and Diabetes
In partnership with the IGSB, Mark Ratain, MD (Department of Medicine, Section of Hematology / Oncology) and colleagues are analyzing genome wide variation in DNA sequence and gene expression in a large collection of human livers to discover patterns of genomic variation and expression. This comprehensive study, never before conducted, will provide the basis for evaluating potential outcomes of drug therapy in individual cancer patients.
About 75% of the top 200 drugs prescribed are eliminated from the body through the metabolic enzymes in the liver. In addition to receiving seed funding as part of the IGSB Metabolic Diseases and Diabetes Initiative, Ratain and colleagues are using the resources of the High Throughput Genome Analysis Core (HGAC) to perform their study.
As part of the same Initiative, Chris Rhodes, PhD (Department of Medicine, Section of Endocrinology, Diabetes and Metabolism) is performing drug and genome screening of insulin-secreting cells in the Celluar Screening Center (CSC) to identify therapies which promote insulin production in diabetes patients.