Inflammatory Bowel Disease
Eugene Chang, MD (Department of Medicine, Section of Gastroenterology) has partnered with IGSB Core Member Dion Antonopoulos, PhD (IGSB, Argonne) to sequence patient gut contents, containing thousands of different bacterial species, to determine the relationship between specific bacteria and inflammatory bowel disease.
This metagenomics project has been supported by seed funding from the Institute’s Inflammatory Bowel Disease Initiative and takes advantage of the next generation sequencing technology within the High-Throughput Genome Analysis Core (HGAC), as well as the computational expertise at Argonne.
Dionysios Antonopolis,
IGSB Core Faculty
Eugene Chang, MD
Director
Digestive Diseases Research Core Center
University of Chicago
Research Papers
- Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci
- Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes
- Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome
- CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
- Robust and tunable circadian rhythms from differentially sensitive catalytic domains
- Integrated genomic analyses of ovarian carcinoma
- A cis-regulatory map of the Drosophila genome
- Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
- A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult
- Orderly wheels of the cyanobacterial clock
