Research Papers
- Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives
- Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan
- Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila
- Novel opportunities for computational biology and sociology in drug discovery
- Extracting physically intuitive reaction coordinates from transition networks of a beta-sheet minipr
- Mutational bias shaping fly copy number variation: implications for genome evolution
Research
IGSB research at the University of Chicago is focused on genomics and systems biology approaches to discover new diagnostic and therapeutic targets, strategies for complex human diseases and basic discoveries of genome function evolution. Our resources are focused on the promotion of research in multiple key areas, and investigators are invited to participate in one or more of these areas as they deem relevant to their own research programs:
- Cancer
- Cellular and Genomic Networks
- Computational Biology and Informatics
- Microbial Systems Biology
- Evolutionary Genomics and Systems
- Population Genomics and Complex Diseases
- Chemical Genomics
- Clinical Genomics
- Proteomics and Structural Genomics
- Biological Engineering and Technology Development
IGSB Initiatives
1000 Chicago Cancer Genome Project
Cancer is, at it heart, a genetic disease, driven by the acquisition of mutations in important genes. Although these mutations produce cancer, recent results in several tumors suggest that these mutations may also represent cancer’s Achilles heel.
Metabolic Diseases and Diabetes
In partnership with the IGSB, Mark Ratain, MD (Department of Medicine, Section of Hematology / Oncology) and colleagues are analyzing genome wide variation in DNA sequence and gene expression in a large collection of human livers to discover patterns of genomic variation and expression.
Inflammatory Bowel Disease
Eugene Chang, MD (Department of Medicine, Section of Gastroenterology) has partnered with IGSB Core Member Dion Antonopoulos, PhD (IGSB, Argonne) to sequence patient gut contents, containing thousands of different bacterial species, to determine the relationship between specific bacteria and inflammatory bowel disease.
$9 million NHGRI award to IGSB team will enable genome-wide discovery of the DNA sequences that regulate genes.
Read press release
The National Institute of General Medical Sciences (NIGMS), has awarded more than $15 million over five years to the University of Chicago to support a new research center—The Chicago Center for Systems Biology—to study how networks of genes work together to enable cells and organisms to respond to environmental and genetic change.
