Michelle Le Beau

Executive Advisory Committee Member, Sr. Fellow,
- Professor, Dept. of Medicine, Section of Hematology/Oncology, University of Chicago
- Director, University of Chicago Cancer Research Center, University of Chicago

Contact Information

The University of Chicago Cancer Research Center
The University of Chicago
5841 S. Maryland Av., AMB H 212Q, MC1140
Chicago, IL 60637

Phone: 773 702 0795
Fax: 773 702 0795
Email: .(JavaScript must be enabled to view this email address)
Website: http://medicine.uchicago.edu/faculty_profile/faculty_profile.asp?empl_id=2718

Research

Human tumors are characterized by recurring chromosomal abnormalities. During the past few years, the genes that are located at the breakpoints of a number of recurring chromosomal abnormalities in human tumors have been identified. Molecular analysis has revealed that alterations in the level of expression of these genes, or in the properties of the encoded proteins resulting from the chromosomal rearrangement, play an integral role in the process of malignant transformation.

My research interests are:

1) to identify the recurring chromosomal abnormalities in human tumors;

2) to correlate specific chromosomal abnormalities with morphological and clinical features of the neoplastic disease, such as response to therapy and survival;

3) to identify the genes located at the breakpoints of the recurring abnormalities using the techniques of molecular genetics, and to examine their function in malignant cells characterized by these chromosomal abnormalities;

4) to localize genes to human chromosomes by using the technique of in situ chromosomal hybridization and to examine the location of specific genes relative to the breakpoints of recurring abnormalities in hematopoietic neoplastic diseases; and

5) to examine the relationship of chromosomal fragile sites (loci which are prone to undergo breakage and rearrangement) and cancer-specific breakpoints.


Research Papers