Marcelo Nobrega

- Asst. Professor, Dept. of Human Genetics, University of Chicago

Contact Information

Department of Human Genetics
The University of Chicago
920 East 58th Street, CLSC 319
Chicago, IL 60637

Phone: 773 834 7919
Fax: 773 834 7919
Email: .(JavaScript must be enabled to view this email address)
Email: .(JavaScript must be enabled to view this email address)


Our group is interested in dissecting the architecture and function of gene regulatory networks. We investigate how the multiple transcription activators, repressors, boundary elements connected to a gene interact and orchestrate the precise tissue-specific and temporal-specific expression pattern of that gene. Understanding this process is critical since it is thought that malfunction of the regulatory program of certain genes underlie the cause of several human diseases. We focus on heart development and congenital heart diseases as substrates to test our hypotheses, and we use mouse and zebrafish genetic engineering, comparative genomics, bioinformatics and other high throughput genomic screening and validation strategies as experimental tools.  

Research Papers