- Professor, Dept. of Human Genetics, University of Chicago
- HHMI Investigator
Department of Human Genetics
The University of Chicago
920 East 58th Street, CLSC 4th Floor
Chicago, IL 60637
Phone: 773 834 5248
Fax: 773 834 5248
My research group tackles the following questions. What is the nature and extent of genetic variation within and between human populations? What are the biological and evolutionary processes that have produced the observed patterns of variation? How do genotypes contribute to phenotypes for complex traits (and how can we identify the relevant genetic variants)?
In our work, we develop new statistical methods for genetic analysis and also analyze data from humans and other organisms. Much of our statistical work makes use of computationally intensive approaches such as Markov chain Monte Carlo; these approaches can be effective for extracting subtle signals from large and complex data sets. In general, we aim to tackle problems where careful analysis, usually from a population genetic perspective, seems likely to yield new biological insights.
The scope of our past and ongoing research includes work in four main areas: (i) methods for gene mapping of complex traits; (ii) inference of population structure from genetic data; (iii) history and structure of human populations; and (iv) genome variation and evolution. We also distribute a number of programs and software packages, including the popular package structure for inferring population structure from genetic data [“Software” link above].
We are based in the Department of Human Genetics at the University of Chicago. Both our department, and the university in general, are very strong in population genetics, complex traits, and evolutionary biology. In particular we enjoy close ties with the labs led by Molly Przeworski, Matthew Stephens, Anna Di Rienzo, Nancy Cox and Carole Ober.