Guillaume Lambert

- Michael Rust Laboratory

Contact Information

The University of Chicago
KCBD 10123C
900 E 57th Street
Chicago, IL 60637

Phone: (773) 795-5650
Email: .(JavaScript must be enabled to view this email address)


One of the most exciting developments in cell biology is the ability to study and quantify the stochastic variability of an organism’s behavior and phenotype. A fundamental question to ask is: can organisms exploit variations in gene expression, which are intrinsic to all biomolecular processes, to enhance the long-term fitness of populations as they respond to environmental perturbations? Over the next few years, I plan to use a physical approach that combines microfluidics technologies and single-cell biology to better understand the evolution and maintenance of regulatory mechanisms that anticipate fluctuating environments and test if they are beneficial, from an evolutionary point of view, to microorganisms. I particular, I am currently studying whether circadian rhythms—self-sustaining biomolecular clocks that coordinate an organism’s behavior and gene expression with the Earth’s 24 hour day—confer a significant and robust evolutionary advantage to populations of cyanobacteria as they are growing under cyclical light variations.

Research Papers