- Professor, Dept. of Chemistry and Institute for Biophysical Dynamics, University of Chicago
Dept. of Chemistry and Institute for Biophysical Dynamics
The University of Chicago
929 E. 57th St., GCIS E 139E
Chicago, IL 60637
Phone: 773 702 2330
Fax: 773 702 2330
The Dinner group develops and applies theoretical methods for relating cellular behavior to molecular properties. We are particularly interested in how proteins regulate access to genes in the context of the development of the immune system. Understanding how such complex behavior arises from physical and chemical features is a problem in fundamental statistical mechanics, but its solution has direct implications for treating autoimmune pathologies and improving gene therapy and vaccination strategies.
One feature that makes theoretical studies of cellular behavior challenging is that the relevant dynamics span a hierarchy of time and length scales ranging from Angstroms and femtoseconds to micrometers and minutes. Experiments are now beginning to bridge gaps in spatial and temporal resolution, and models are vital for design and interpretation of such measurements. Our research thus blends atomic-resolution simulations with coarse-grained numerical and analytical approaches, often in collaboration with experimental groups.