- Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1
- A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk
- A Comprehensive Nuclear Receptor Network for Breast Cancer Cells
- Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation
- A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community
- Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis
- Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants
- Rapid quantification of sequence repeats to resolve the size, structure and contents of bacterial genomes
- Representation of probabilistic scientific knowledge
- Studying the microbiology of the indoor environment
IGSB/CBC Postdoctoral Fellow Aly Khan co-authored a study on a previously unknown interaction between gut bacteria and gender bias in autoimmune diseases. The study proposes a novel two-signal model, in which hormones and microbes together influence the incidence and severity of autoimmune diseases. The results were published in Cell Immunity and are highlighted in a featured article in the issue.
Congratulations to Ernst Lengyel, Hillary Kenny, Christopher Gomez, Marsha Rosner and Kay MacLeod, who have been awarded grants from the Chicago Biomedical Consortium in support of high throughput screening projects. They will be working with the Cellular Screening Center to develop their small molecule screens for drug discovery.
The 10-week Chicago Center for Systems Biology summer REU program kicked off this past Tuesday. Students will work in the labs of Kevin White, Michael Rust, Richard Carthew, Rick Morimoto and Ilya Ruvinsky, on projects ranging from circadian rhythms in cyanobacteria to Drosophila development.
Bionimbus, an advanced cloud-based computing environment, helped Megan McNerney discover tumor suppressor gene, CUX1, is frequently inactivated in acute myeloid leukemia. The principal investigator for Bionimbus is Robert Grossman.
Two major gifts will build momentum behind the University of Chicago’s leadership in biomedical computation by assembling experts in the field and furnishing them with the tools to use “big data” to understand and treat disease. Kevin White and Robert Grossman will lead the Pancreatic Cancer Genomic Medicine Initiative, which aims to improve care for patients with this disease using genomic and physiological data.
Barbara Stranger and colleagues take a systems approach, integrating GWAS, eQTL and protein interaction data, to demonstrate that loci associated with inflammatory disease susceptibility are enriched for genomic signatures of recent evolutionary selection. Their analyses suggest that natural selection for pathogen-defense mechanisms through human evolution may underlie modern susceptibility to inflammatory diseases.
The annual list, published by Federal Computer Week, recognizes government, industry and academic leaders who have played pivotal roles in the federal government IT community.
In response to the community-wide interest in High Throughput Screening, the Chicago Biomedical Consortium is offering a 1:1 HTS Matching Grant Program to help fund innovative small molecule discovery. The intent of this program is to support pilot projects involving bio medically-relevant targets using a HTS facility located at one of the CBC universities, including the IGSB’s Cellular Screening Center.