- Transcription Factor Networks In Drosophila Melanogaster
- Mixtures of opposing phosphorylations within hexamers precisely time feedback in the cyanobacterial circadian clock
- Intersection of population variation and autoimmunity genetics in human T cell activation
- Longitudinal analysis of microbial interaction between humans and the indoor environment
- Comparative Analysis of Regulatory Information and Circuits Across Distant Species
- Commensal Bacteria Protect Against Food Allergen Sensitization
- Rhythms in Energy Storage Control the Ability of the Cyanobacterial Circadian Clock to Reset
- Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change.
- SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
- Low grade prostate cancer diverges early from high grade and metastatic disease.
IGSB Core Member Jack Gilbert was honored by Crain’s Chicago Business as a proven leader in his field. Previous winners before their 40th birthday include Barack Obama, Nate Silver, and Kevin White.
With a contract with the National Cancer Institute (NCI), IGSB Core Investigator Robert Grossman will be Director of the Genomic Data Commons (GDC). This initiative will establish the nation’s most comprehensive computational facility to collect, standardize, store, and disseminate genomic information gathered by NCI. The GDC will provide an interactive system to expand access for scientists around the country, speed up collaborative research on projects at all scales, and lead to faster discoveries about cancer.
NIH funding to develop a Big Data traveling exhibition for science museums and schools was received as a result of a 1-year supplemental grant produced by IGSB Education & Outreach Director Barry Aprison for the Genes and Addiction NIDA Center for GWAS in Outbred Rats project. Abraham Palmer is PI of the NIDA Center program.
Student members of the Genehackers UChicago team successfully submitted biobricks at the International Genetically Engineered Machines (iGEM) Giant Jamboree in Boston. The project, “A Sequence Space Odyssey: Diversifying Mutators to Optimize Directed Evolution,” was awarded a Bronze Medal.
IGSB core investigator Barbara Stranger received supplemental funding from NIH to explore the effects of gender on human traits. Her group will characterize these differences and determine what underlies them. This new funding will allow her lab to focus on how gender influences the relationship between genetic differences among individuals and variation in protein levels among individuals and across tissues, with an ultimate goal of understanding how this influences disease susceptibility. Her lab also received funding to specifically investigate the role of gender in pharmacogenomics phenotypes and neuropsychiatric phenotypes (with IGSB core member Andrey Rzhetsky). For more information, click here.
IGSB students in Mike Rust's lab are collaborating on an International Genetically Engineered Machines (iGEM) project about synthetic biology. IGSB team members are using standardized biological parts provided by iGEM and molecular components they have devised to engineer E.coli mutator strains that can optimize the production of a desired metabolite using a novel technique in directed evolution. The team will go to the 2014 iGEM jamboree at MIT to present their research. Participating iGEM teams from around the world will also attend and demonstrate synthetic living systems with innovative functions and capabilities.
IGSB Research Professional, Dr. Audrey Fu, was awarded a K99 NIH grant to support a research project entitled: Causal Inference of Gene Regulatory Networks with Application to Breast Cancer. The aim is to develop statistical models and computational methods for the inference of causal gene regulatory networks. The project will investigate how genetic variation acting on biological networks influences development and progression of diseases, using subtypes of breast cancer as a disease model.
Seven undergraduates in the Conte Center’s Computational Neuropsychiatric Genomics REU Program and four undergraduates in the Chicago Center for Systems Biology’s REU Program are working on summer research projects. Both REU groups participated in a journal club at the University of Chicago’s Quad Club.
IGSB Core Member, Mike Rust, was
honored today by being named a Pew
Scholar in the Biomedical Sciences by the
Pew Charitable Trusts. Pew Scholars are
selected by a national advisory committee.
They receive flexible funding over four
years to seed innovation at the start of
independent research careers.
IGSB investigators Bob Grossman and Megan McNerney
are highlighted in an Outlook Cancer: Bioinformatics profile in the May 29, 2014 issue of Nature.
Barbara Stranger and her lab led analyses of data published in the journal, Science. The report, “Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes,” demonstrates how genetic variations among healthy, young individuals can influence immune cell function. Many of those variants are also genetic risk factors for Alzheimer’s disease, diabetes, and multiple sclerosis later in life, offering new insight into disease pathology.
TRAVEL ABROAD WHILE RESEARCHING THE LATEST TECHNOLOGIES IN CLOUD COMPUTING WITH NSF FUNDED OSDC-PIRE FELLOWSHIP DEADLINE: April 30, 2014
The Open Science Data Cloud PIRE project provides international research and education experiences through training and study at universities and research institutes around the world with leading scientists in computing. Increase your expertise in managing and analyzing data.
Madison Olmsted, from Rio Americano High School in Sacramento, California, participated in a Research in Biological Sciences, Part 2 (RIBS-2) program in Kevin White’s lab last summer.