Research Papers
- Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes
- CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
- Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci
- Robust and tunable circadian rhythms from differentially sensitive catalytic domains
- A cis-regulatory map of the Drosophila genome
- Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
- Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome
- A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult
- Orderly wheels of the cyanobacterial clock
- Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks
Latest News
IGSB welcomes the 2013 CCSB summer REU students
The 10-week Chicago Center for Systems Biology summer REU program kicked off this past Tuesday. Students will work in the labs of Kevin White, Michael Rust, Richard Carthew, Rick Morimoto and Ilya Ruvinsky, on projects ranging from circadian rhythms in cyanobacteria to Drosophila development.
Gifts to boost University of Chicago as hub for biomedical ‘big data’
Two major gifts will build momentum behind the University of Chicago’s leadership in biomedical computation by assembling experts in the field and furnishing them with the tools to use “big data” to understand and treat disease. Kevin White and Robert Grossman will lead the Pancreatic Cancer Genomic Medicine Initiative, which aims to improve care for patients with this disease using genomic and physiological data.
Immunity, inflammation and natural selection
Barbara Stranger and colleagues take a systems approach, integrating GWAS, eQTL and protein interaction data, to demonstrate that loci associated with inflammatory disease susceptibility are enriched for genomic signatures of recent evolutionary selection. Their analyses suggest that natural selection for pathogen-defense mechanisms through human evolution may underlie modern susceptibility to inflammatory diseases.
Robert Grossman named a Federal 100 Award winner
The annual list, published by Federal Computer Week, recognizes government, industry and academic leaders who have played pivotal roles in the federal government IT community.
CBC announces a high throughput screening award
In response to the community-wide interest in High Throughput Screening, the Chicago Biomedical Consortium is offering a 1:1 HTS Matching Grant Program to help fund innovative small molecule discovery. The intent of this program is to support pilot projects involving bio medically-relevant targets using a HTS facility located at one of the CBC universities, including the IGSB’s Cellular Screening Center.
A network of nuclear receptors
By mapping the bindings sites of nuclear receptors, chromatin state markers and transcription factors associated with breast cancer, IGSB Director Kevin White and colleagues construct a network representing different types of regulatory relationships. Their analyses identifies transcriptions factors with previously unsuspected roles in breast cancer and enables predictions of responses to therapy.
