- Rhythms in Energy Storage Control the Ability of the Cyanobacterial Circadian Clock to Reset
- Protein quantitative trait loci identify novel candidates modulating cellular response to chemotherapy.
- Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change.
- SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
- Defining functional DNA elements in the human genome.
- Low grade prostate cancer diverges early from high grade and metastatic disease.
- The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).
- Evolution of H3K27me3-marked chromatin is linked to gene expression evolution and to patterns of gene duplication and diversification.
- Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster.
- Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
IGSB students in Mike Rust's lab are collaborating on an International Genetically Engineered Machines (iGEM) project about synthetic biology. IGSB team members are using standardized biological parts provided by iGEM and molecular components they have devised to engineer E.coli mutator strains that can optimize the production of a desired metabolite using a novel technique in directed evolution. The team will go to the 2014 iGEM jamboree at MIT to present their research. Participating iGEM teams from around the world will also attend and demonstrate synthetic living systems with innovative functions and capabilities.
IGSB Research Professional, Dr. Audrey Fu, was awarded a K99 NIH grant to support a research project entitled: Causal Inference of Gene Regulatory Networks with Application to Breast Cancer. The aim is to develop statistical models and computational methods for the inference of causal gene regulatory networks. The project will investigate how genetic variation acting on biological networks influences development and progression of diseases, using subtypes of breast cancer as a disease model.
Seven undergraduates in the Conte Center’s Computational Neuropsychiatric Genomics REU Program and four undergraduates in the Chicago Center for Systems Biology’s REU Program are working on summer research projects. Both REU groups participated in a journal club at the University of Chicago’s Quad Club.
IGSB Core Member, Mike Rust, was
honored today by being named a Pew
Scholar in the Biomedical Sciences by the
Pew Charitable Trusts. Pew Scholars are
selected by a national advisory committee.
They receive flexible funding over four
years to seed innovation at the start of
independent research careers.
IGSB investigators Bob Grossman and Megan McNerney
are highlighted in an Outlook Cancer: Bioinformatics profile in the May 29, 2014 issue of Nature.
Barbara Stranger and her lab led analyses of data published in the journal, Science. The report, “Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes,” demonstrates how genetic variations among healthy, young individuals can influence immune cell function. Many of those variants are also genetic risk factors for Alzheimer’s disease, diabetes, and multiple sclerosis later in life, offering new insight into disease pathology.
TRAVEL ABROAD WHILE RESEARCHING THE LATEST TECHNOLOGIES IN CLOUD COMPUTING WITH NSF FUNDED OSDC-PIRE FELLOWSHIP DEADLINE: April 30, 2014
The Open Science Data Cloud PIRE project provides international research and education experiences through training and study at universities and research institutes around the world with leading scientists in computing. Increase your expertise in managing and analyzing data.
Madison Olmsted, from Rio Americano High School in Sacramento, California, participated in a Research in Biological Sciences, Part 2 (RIBS-2) program in Kevin White’s lab last summer.