Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives (Development July 15, 2010)
Development. 2010 Jul;137(14):2265-78.
Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.
Graham TG, Tabei SM, Dinner AR, Rebay I.
Ben May Department for Cancer Research, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
Abstract
A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used to understand and predict the bistable or multistable behavior of such networks.
Research Papers
- Light-Driven Changes in Energy Metabolism Directly Entrain the Cyanobacterial Circadian Oscillator
- A Vision for a Biomedical Cloud (J Intern Med. 2011 Dec 5. doi: 10.1111/j.1365-2796.2011.02491)
- Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness (Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America)
- Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.
- Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data (Proc Natl Acad Sci U S A. 2011 Jul 5.)
- A user's guide to the encyclopedia of DNA elements (ENCODE). (PLoS Biol. 2011 Apr;9(4):e1001046. Epub 2011 Apr 19)