Gene regulatory networks in the immune system
We describe examples of genomic control circuits that underlie developmental transitions and cellular activation states within the immune system. The architectures of simple gene regulatory networks (GRNs) are highlighted to emphasize conservation of regulatory motifs. The regulatory logic and the cell fate dynamics of each simple GRN, the latter revealed by mathematical and computational modeling, are elaborated. This framework is being expanded to enable the assembly and analysis of complex GRNs using genomic, computational, and high-throughput experimental methodologies. The paradigm will provide new insights into immune cell development and function, and into the pathophysiology of autoimmune and inflammatory disorders, as well as immune malignancies.
Research Papers
- Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
- Conjunction of factors triggering waves of seasonal influenza
- Algorithmic Bio-surveillance For Precise Spatio-temporal Prediction of Zoonotic Emergence
- Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry
- Does the brain listen to the gut?
- (Meta)genomic insights into the pathogenome of Cellulosimicrobium cellulans
- A robust adaptive denoising framework for real-time artifact removal in scalp EEG measurements
- Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx
- Small Rad51 and Dmc1 Complexes Often Co-occupy Both Ends of a Meiotic DNA Double Strand Break
- Controlling the Cyanobacterial Clock by Synthetically Rewiring Metabolism
