Computational Recipes in Enzymology

How do rich biological behaviors arise from bi-molecular collisions? Living cells are capable of a remarkably diverse spectrum of behaviors in response to cues from their environment. These behaviors range from switch-like responses, to the ability to detect minute variations in stimulus against a uniform background, to the generation of self-sustaining oscillations. The quantitative properties of cellular behavior can often be usefully summarized by an input-output relationship (similar to a dose-response curve), allowing us to visualize the response of a system as a function of an applied stimulus.

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PMID: 27135910