Noise Induces Hopping between NF-κB Entrainment Modes

Noise Induces Hopping between NF-κB Entrainment Modes

Oscillations and noise drive many processes in biology, but how both affect the activity of the transcription factor nuclear factor κB (NF-κB) is not understood. Here, we observe that when NF-κB oscillations are entrained by periodic tumor necrosis factor (TNF) inputs in experiments, NF-κB exhibits jumps between frequency modes, a phenomenon we call “cellular mode-hopping.” By comparing stochastic simulations of NF-κB oscillations to deterministic simulations conducted inside and outside the chaotic regime of parameter space, we show that noise facilitates mode-hopping in all regimes. However, when the deterministic system is driven by chaotic dynamics, hops between modes are erratic and short-lived, whereas in experiments, the system spends several periods in one entrainment mode before hopping and rarely visits more than two modes. The experimental behavior matches our simulations of noise-induced mode-hopping outside the chaotic regime. We suggest that mode-hopping is a mechanism by which different NF-κB-dependent genes under frequency control can be expressed at different times. The full article can be read here.

Latest News

Start-up founded by IGSB faculty wins $250,000 Polsky Center award

BiomeSense, a startup developing biosensors that can detect particular kinds of bacteria in patients’ feces that could help improve the efficacy of clinical trials, won the University of Chicago’s Innovation Fund finals and an investment of up to $250,000 from the college.

Massive data analysis shows what drives the spread of flu in the US

Models built with data from health claims, weather, geography and Twitter predict how the flu spreads from the south and southeastern coast

Subscribe to RSS Feed