IGSB Core Faculty Robert Grossman appointed Chief Research Informatics Officer of the Division of the Biological Sciences
Department of Medicine and the College
Robert Grossman is a faculty member in the Section of Genetic Medicine, as well as the chief research informatics officer for the Division of the Biological Sciences. He is also a senior fellow in the Computation Institute and the Institute for Genomics and Systems Biology. His research group focuses on bioinformatics, data mining, cloud computing, data intensive computing, and related areas. He is also the founder of Open Data Group, which has provided strategic consulting and outsourced services in analytics since 2002, specializing in building predictive models over big data. His current research is focused on bioinformatics, especially developing systems, applications, and algorithms so that large datasets of genomics data can be integrated with phenotype information extracted from electronic medical records and analyzed to deepen our understanding of diseases.
Most recently, Grossman was a Pritzker Scholar at the University of Chicago in 2011; the overall winner, SC 09 Bandwidth Challenge for “Maximizing Bandwidth Utilization in Distributed Data Intensive Applications”; and first place winner, SC 08 Bandwidth Challenge for “Towards Global Scale Cloud Computing: Using Sector and Sphere on the Open Cloud Testbed.”
He serves on the NASA Advisory Council Information Technology Infrastructure Committee.
Grossman earned his PhD in applied mathematics at Princeton University and an AB in mathematics from Harvard University.
Two major gifts will build momentum behind the University of Chicago’s leadership in biomedical computation by assembling experts in the field and furnishing them with the tools to use “big data” to understand and treat disease. Kevin White and Robert Grossman will lead the Pancreatic Cancer Genomic Medicine Initiative, which aims to improve care for patients with this disease using genomic and physiological data.
Barbara Stranger and colleagues take a systems approach, integrating GWAS, eQTL and protein interaction data, to demonstrate that loci associated with inflammatory disease susceptibility are enriched for genomic signatures of recent evolutionary selection. Their analyses suggest that natural selection for pathogen-defense mechanisms through human evolution may underlie modern susceptibility to inflammatory diseases.
The annual list, published by Federal Computer Week, recognizes government, industry and academic leaders who have played pivotal roles in the federal government IT community.
In response to the community-wide interest in High Throughput Screening, the Chicago Biomedical Consortium is offering a 1:1 HTS Matching Grant Program to help fund innovative small molecule discovery. The intent of this program is to support pilot projects involving bio medically-relevant targets using a HTS facility located at one of the CBC universities, including the IGSB’s Cellular Screening Center.
By mapping the bindings sites of nuclear receptors, chromatin state markers and transcription factors associated with breast cancer, IGSB Director Kevin White and colleagues construct a network representing different types of regulatory relationships. Their analyses identifies transcriptions factors with previously unsuspected roles in breast cancer and enables predictions of responses to therapy.