Nucleic Acid Sequence Is a Universal Information Substrate of All Life

Speaker

Viktor Stolc, Director, NASA Ames Genome Research Facility

Date

February 16, 2007, 12:00 pm – 12:30 pm

Location

Bldg. 440, A105 & A106, Argonne National Laboratory

Description

In partnership with several universities, NASA Ames Genome Research Facility has developed novel applications of high-density DNA oligonucleotide microarrays for probing RNA expression of both protein-coding and non-protein-coding sequences in the completed genomes of several model organisms and the human genome. Computational methods for the design and analysis of the whole-genome tiling microarrays were developed by using the NASA Ames supercomputer. This work resulted in the confirmation of nearly all previous gene expression results generated with other techniques, and identified thousands of genes and RNA transcripts that were previously undescribed by all other methods.

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