How the genome folds


Erez Lieberman Aiden, PhD


November 8, 2011, 3:30 pm – 4:30 pm




IGSB-SM How the genome folds

Submitting Unit
Genomics & Systems Biology, Institute for Type of Event
Date of Event
Tuesday, November 8 2011 Start Time
03:30 PM End Time
04:30 PM Building
Knapp Center for Biomedical Discovery Room

Name of Series, Lectureship, Ceremony
IGSB Special Seminar

Title of talk or presentation
How the genome folds

Speaker’s Name and Degrees
Erez Lieberman Aiden, PhD

Speaker’s Institutional Affiliation
Harvard University

IGSB Special Seminar

Erez Lieberman Aiden, Ph.D.
Fellow, Harvard Society of Fellows
Principal Investigator, Harvard Laboratory-at-Large
Harvard University

“How the genome folds”

Tuesday, November 8, 2011
3:30 p.m.-4:30 p.m.

Knapp Center for Biomedical Discovery
1st Floor Auditorium, Room 1103
900 E. 57th Street

I describe Hi-C, a novel technology for probing the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. Working with collaborators at the Broad Institute and UMass Medical School, we used Hi-C to construct spatial proximity maps of the human genome at a resolution of 1Mb. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and closed chromatin to form two genome-wide compartments. At the megabase scale, the chromatin conformation is consistent with a fractal globule, a knot-free conformation that enables maximally dense packing while preserving the ability to easily fold and unfold any genomic locus. The fractal globule is distinct from the more commonly used globular equilibrium model. Our results demonstrate the power of Hi-C to map the dynamic conformations of whole genomes.

Contact Name
Liza Herendeen

Contact Email

Contact Phone

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